亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

A review of statistical strategies to integrate biomarkers of chemical exposure with biomarkers of effect applied in omic-scale environmental epidemiology

暴露的 环境流行病学 数据科学 工作流程 仿形(计算机编程) 组学 计算生物学 计算机科学 生物信息学 环境卫生 生物 医学 数据库 操作系统
作者
Étienne Babin,Germán Cano-Sancho,Évelyne Vigneau,Jean‐Philippe Antignac
出处
期刊:Environmental Pollution [Elsevier BV]
卷期号:330: 121741-121741 被引量:5
标识
DOI:10.1016/j.envpol.2023.121741
摘要

Humans are exposed to a growing list of synthetic chemicals, some of them becoming a major public health concern due to their capacity to impact multiple biological endpoints and contribute to a range of chronic diseases. The integration of endogenous (omic) biomarkers of effect in environmental health studies has been growing during the last decade, aiming to gain insight into potential mechanisms linking the exposures and the clinical conditions. The emergence of high-throughput omic platforms has raised a list of statistical challenges posed by the large dimension and complexity of data generated. Thus, the aim of the present study was to critically review the current state-of-the-science about statistical approaches used to integrate endogenous biomarkers in environmental-health studies linking chemical exposures with health outcomes. The present review specifically focused on internal exposure to environmental chemical pollutants, involving both persistent organic pollutants (POPs) and non-persistent pollutants like phthalates or bisphenols, and metals. We identified 42 eligible articles published since 2016, reporting 48 different statistical workflows, mostly focused on POPs and using metabolomic profiling in the intermediate layer. The outcomes were mainly binary and focused on metabolic disorders. A large diversity of statistical strategies were reported to integrate chemical mixtures and endogenous biomarkers to characterize their associations with health conditions. Multivariate regression models were the most predominant statistical method reported in the published workflows, however some studies applied latent based methods or multipollutant models to overcome the specific constraints of omic or exposure data. A minority of studies used formal mediation analysis to characterize the indirect effects mediated by the endogenous biomarkers. The principles of each specific statistical method and overall workflow set-up are summarized in the light of highlighting their applicability, strengths and weaknesses or interpretability to gain insight into the causal structures underlying the triad: exposure, effect-biomarker and outcome.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
26秒前
47秒前
Tiger完成签到,获得积分10
56秒前
59秒前
1分钟前
Ma发布了新的文献求助10
1分钟前
1分钟前
1分钟前
科研通AI5应助Ma采纳,获得10
1分钟前
彼岸花开发布了新的文献求助10
1分钟前
2分钟前
易四夕发布了新的文献求助10
2分钟前
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
Ma发布了新的文献求助10
2分钟前
1234完成签到,获得积分10
3分钟前
岁和景明完成签到 ,获得积分10
3分钟前
科研通AI5应助Ma采纳,获得10
3分钟前
西蓝花香菜完成签到 ,获得积分10
3分钟前
4分钟前
4分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
Ma发布了新的文献求助10
4分钟前
4分钟前
科研通AI5应助Ma采纳,获得10
5分钟前
忧伤的绍辉完成签到 ,获得积分10
5分钟前
隐形曼青应助易四夕采纳,获得10
5分钟前
5分钟前
易四夕发布了新的文献求助10
6分钟前
6分钟前
6分钟前
Ma发布了新的文献求助10
6分钟前
6分钟前
随机子发布了新的文献求助10
6分钟前
6分钟前
Ava应助科研通管家采纳,获得10
6分钟前
科目三应助科研通管家采纳,获得10
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167214
捐赠科研通 3248660
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638