化学
丝氨酸
半胱氨酸
生物化学
磷酸化
马尔克斯
葛兰素史克-3
氨基酸
激酶
苏氨酸
蛋白激酶B
酶
肉豆蔻酰化
出处
期刊:Chirality
[Wiley]
日期:2023-03-08
卷期号:35 (9): 535-539
摘要
Mammalian D-Cysteine is racemized from L-cysteine by serine racemase, a pyridoxal phosphate (PLP)-dependent enzyme. Endogenous D-Cysteine plays a role in neural development by inhibiting proliferation of neural progenitor cells (NPCs) via protein kinase B (AKT) signaling mediated by the FoxO family of transcription factors. D-Cysteine binds to Myristoylated Alanine Rich C Kinase Substrate (MARCKS) and alters phosphorylation at Ser 159/163 and its translocation from the membrane. By racemizing serine and cysteine, mammalian serine racemase may play important roles in neural development highlighting its importance in psychiatric disorders.
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