Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients: a single-centre study

医学 重症监护室 中医药 2019年冠状病毒病(COVID-19) 观察研究 病危 重症监护 内科学 死亡率 重症监护医学 中西医结合 急诊医学 替代医学 疾病 病理 传染病(医学专业)
作者
Yongjiu Xiao,Binbin Li,Chang Liu,Xiuyu Huang,Ling Ma,Zhirong Qian,Xiaopeng ZHANG,Shouxin Zhang,Dunqing Li,Xiaoqing CAI,Xiangyong Yan,Luo Shuping,Dawei Xiang,Kun Xiao
出处
期刊:Chinese Journal of Natural Medicines [Elsevier]
卷期号:22 (1): 89-96
标识
DOI:10.1016/s1875-5364(24)60565-0
摘要

As the search for effective treatments for COVID-19 continues, the high mortality rate among critically ill patients in Intensive Care Units (ICU) presents a profound challenge. This study explores the potential benefits of traditional Chinese medicine (TCM) as a supplementary treatment for severe COVID-19. A total of 110 critically ill COVID-19 patients at the Intensive Care Unit (ICU) of Vulcan Hill Hospital between Feb., 2020, and April, 2020 (Wuhan, China) participated in this observational study. All patients received standard supportive care protocols, with a subset of 81 also receiving TCM as an adjunct treatment. Clinical characteristics during the treatment period and the clinical outcome of each patient were closely monitored and analysed. Our findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group (16 of 81 vs 24 of 29; 0.3 vs 2.3 person/month). In the adjusted Cox proportional hazards models, TCM treatment was associated with improved survival odds (P < 0.001). Furthermore, the analysis also revealed that TCM treatment could partially mitigate inflammatory responses, as evidenced by the reduced levels of proinflammatory cytokines, and contribute to the recovery of multiple organic functions, thereby potentially increasing the survival rate of critically ill COVID-19 patients.
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