穿心莲内酯
药物输送
纳米材料
共轭体系
材料科学
纳米技术
纳米颗粒
量子点
碳量子点
碳纤维
药品
化学
化学工程
有机化学
聚合物
心理学
精神科
复合数
工程类
复合材料
作者
Nataniel Medina-Berríos,Wenndy Pantoja-Romero,Alexis Lavín Flores,Sebastián C. Díaz Vélez,Anna C. Martínez Guadalupe,Mariana T. Torres Mulero,Kim Kisslinger,Magaly Martínez‐Ferrer,Gerardo Morell,Brad R. Weiner
出处
期刊:ACS omega
[American Chemical Society]
日期:2024-03-06
被引量:2
标识
DOI:10.1021/acsomega.3c06252
摘要
Carbon-based quantum dots (CBQDs), sulfur-doped carbon-based quantum dots (S-CBQDs), and nitrogen-doped carbon-based quantum dots (N-CBQDs) have strong potential for drug delivery platforms. They were conjugated with andrographolide, a well-known hydrophobic drug, to study the concomitant changes in hydrophilicity. The interactions between these nanomaterials and the drug were studied by characterizing the optical and structural properties of the nanoparticles before and after coupling with the drug. It was found that the interaction of the drug with these nanomaterials produced noticeable changes in their optical and structural properties. Moreover, the partition coefficient for the nanocomposites was determined by NMR. The results indicate that conjugating the drug with the nanoparticles significantly enhanced its affinity for the aqueous phase, from 2.632 to 0.1117, thereby opening the possibility of using this approach for developing an effective drug delivery platform for this hydrophobic drug.
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