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神经科学
荟萃分析
功能连接
心理学
静息状态功能磁共振成像
重性抑郁障碍
临床心理学
医学
认知
内科学
作者
Zilin Zhou,Yingxue Gao,Weijie Bao,Kaili Liang,Lingxiao Cao,Mengyue Tang,Hailong Li,Xinyue Hu,Lianqing Zhang,Huaiqiang Sun,Neil Roberts,Qiyong Gong,Xiaoqi Huang
标识
DOI:10.1016/j.neubiorev.2024.105583
摘要
Evidence of whether the intrinsic functional connectivity of anterior cingulate cortex (ACC) and its subregions is altered in major depressive disorder (MDD) remains inconclusive. A systematic review and meta-analysis were therefore performed on the whole-brain resting-state functional connectivity (rsFC) studies using the ACC and its subregions as seed regions in MDD, in order to draw more reliable conclusions. Forty-four ACC-based rsFC studies were included, comprising 25 subgenual ACC-based studies, 11 pregenual ACC-based studies, and 17 dorsal ACC-based studies. Specific alterations of rsFC were identified for each ACC subregion in patients with MDD, with altered rsFC of subgenual ACC in emotion-related brain regions, of pregenual ACC in sensorimotor-related regions, and of dorsal ACC in cognition-related regions. Furthermore, meta-regression analysis revealed a significant negative correlation between the pgACC-caudate hypoconnectivity and percentage of female patients in the study cohort. This meta-analysis provides robust evidence of altered intrinsic functional connectivity of the ACC subregions in MDD, which may hold relevance to understanding the origin of, and treating, the emotional, sensorimotor and cognitive dysfunctions that are often observed in these patients.
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