医学
过敏
个性化医疗
变应原免疫治疗
药方
重症监护医学
精密医学
呼吸道过敏
过敏原
免疫学
生物信息学
药理学
病理
生物
作者
Gustavo Falbo Wandalsen,Fernando Monteiro Aarestrup,Dirceu Solé
出处
期刊:Current Opinion in Allergy and Clinical Immunology
[Ovid Technologies (Wolters Kluwer)]
日期:2024-02-12
卷期号:24 (2): 88-93
被引量:2
标识
DOI:10.1097/aci.0000000000000968
摘要
Purpose of review To review recent evidence on allergen immunotherapy (AIT) as a model of personalized medicine in the treatment of children and adolescents with respiratory allergies. Recent findings Meta-analysis and systematic review studies continue to point out that AIT is an effective treatment for children with respiratory allergies. Molecular allergy allows the understanding of patient sensitization profiles that frequently change the prescription of AIT. There is still a lack of evidence showing that this personalized prescription of AIT is associated with better clinical outcomes. The nasal allergen challenge has extended the indications of AIT for a new group of subjects with local allergic rhinitis. Patient selection of allergens involved in the increasingly personalized composition of extracts to be used in AIT increasingly characterizes it as personalized medicine. Summary Despite the numerous studies carried out to identify the best biomarker to evaluate the response to AIT, there is still much disagreement, and clinical assessment (symptoms, quality of life, among others) continues to be the best way to evaluate the therapeutic success of AIT.
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