Preventing viral relapse with prophylactic tenofovir in hepatitis B carriers receiving chemotherapy: a phase IV randomized study in Taiwan

医学 内科学 乙型肝炎病毒 乙型肝炎 胃肠病学 乙型肝炎表面抗原 随机对照试验 累积发病率 肝病学 化疗 免疫学 病毒 移植
作者
Chao‐Wei Hsu,Shin‐Cheh Chen,Po‐Nan Wang,Hung‐Ming Wang,Yi-Cheng Chen,Chau‐Ting Yeh
出处
期刊:Hepatology International [Springer Science+Business Media]
被引量:1
标识
DOI:10.1007/s12072-023-10635-5
摘要

This study aimed to compare the efficacy of shorter vs. longer tenofovir disoproxil fumarate (TDF) prophylaxis in preventing hepatitis B virus (HBV) relapse in cancer patients with chronic hepatitis B (CHB) undergoing chemotherapy. This phase IV, prospective randomized trial enrolled cancer patients with CHB from 2014 to 2019 in Taiwan. Included patients were randomized to receive either 24- (Arm A) or 48-week (Arm B) post-chemotherapy TDF and compared for cumulative incidence of virological and clinical relapse. Logistic regressions were conducted to determine the factors associated with HBV relapse. One hundred patients were randomized, and 41 patients in Arm A and 46 in Arm B completed the TDF treatment. No significant difference was found in cumulative incidence of virological relapse (Arm A: 94.4%, Arm B: 93.1%, p = 0.110) or clinical relapse among patients with baseline HBV DNA > 2000 IU/mL (Arm A: 38.9%, Arm B: 26.7%, p = 0.420) between the two arms. High baseline HBV DNA ≥ 10,000 IU/mL (OR = 51.22) and HBsAg ≥ 1000 IU/mL (OR = 8.64) were independently associated with an increased virological relapse. Alanine aminotransferase (ALT), serum phosphorus, vitamin D, and estimated glomerular filtration rate (eGFR) remained stable throughout the study. The 24-week preventative TDF has comparable efficacy to the 48-week treatment in virologic and clinical relapse. High baseline HBsAg or HBV DNA is associated with a higher risk of HBV relapse. These findings imply a 24-week duration of TDF treatment with a close monitor for patients with a high baseline viral load. Hepatitis B virus infection is a prominent cause of liver cancer and chronic liver disease and affected millions of people worldwide. When HBV-infected people are exposed to immunosuppressive medication or chemotherapy for cancer, the chance of HBV reactivation rises considerably. This trial showed 24-week tenofovir disoproxil fumarate (TDF) may be sufficient for preventing HBV relapse in cancer patients receiving chemotherapy. NCT02081469.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
shinn发布了新的文献求助20
刚刚
刚刚
猛猛冲发布了新的文献求助10
1秒前
慕青应助西西采纳,获得10
1秒前
1秒前
量子星尘发布了新的文献求助10
3秒前
扶桑发布了新的文献求助10
3秒前
Hello应助自信念云采纳,获得10
4秒前
5秒前
Asteria完成签到,获得积分10
7秒前
仲达发布了新的文献求助10
7秒前
7秒前
能干的邹完成签到 ,获得积分10
7秒前
所所应助王梦豪采纳,获得10
8秒前
8秒前
8秒前
Jasper应助董豆豆采纳,获得10
9秒前
叽里呱啦完成签到 ,获得积分10
10秒前
坦率的路人完成签到,获得积分10
10秒前
清脆的土豆完成签到,获得积分0
11秒前
易逢春发布了新的文献求助10
11秒前
12秒前
领导范儿应助shinn采纳,获得10
13秒前
内向寒云发布了新的文献求助10
13秒前
13秒前
Mr.Jian完成签到,获得积分10
14秒前
14秒前
猛猛冲完成签到,获得积分10
15秒前
研友_ZGjRjn发布了新的文献求助10
15秒前
smottom应助斯文的傲珊采纳,获得10
16秒前
淦淦完成签到,获得积分20
16秒前
18秒前
打打应助欣慰的乌冬面采纳,获得10
19秒前
SUN应助宋宋宋2采纳,获得10
19秒前
21秒前
大梅子清清淡淡完成签到,获得积分10
21秒前
乐乐应助carnationli采纳,获得10
21秒前
24秒前
123456发布了新的文献求助10
26秒前
27秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975339
求助须知:如何正确求助?哪些是违规求助? 3519670
关于积分的说明 11199199
捐赠科研通 3256002
什么是DOI,文献DOI怎么找? 1798043
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305