谷氨酸的
脊髓损伤
脊髓
神经科学
光遗传学
兴奋性突触后电位
病变
神经可塑性
网状结构
医学
生物
中枢神经系统
谷氨酸受体
抑制性突触后电位
病理
内科学
受体
作者
Maxime Lemieux,Narges Karimi,Frédéric Bretzner
标识
DOI:10.1038/s41467-024-45300-4
摘要
Abstract Spinal cord injury disrupts the descending command from the brain and causes a range of motor deficits. Here, we use optogenetic tools to investigate the functional plasticity of the glutamatergic reticulospinal drive of the medullary reticular formation after a lateral thoracic hemisection in female mice. Sites evoking stronger excitatory descending drive in intact conditions are the most impaired after injury, whereas those associated with a weaker drive are potentiated. After lesion, pro- and anti-locomotor activities (that is, initiation/acceleration versus stop/deceleration) are overall preserved. Activating the descending reticulospinal drive improves stepping ability on a flat surface of chronically impaired injured mice, and its priming enhances recovery of skilled locomotion on a horizontal ladder. This study highlights the resilience and capacity for reorganization of the glutamatergic reticulospinal command after injury, along with its suitability as a therapeutical target to promote functional recovery.
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