Dynamic Kinetic Resolution of α-F-β-Ketone Amides (Esters) via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation

Chiral fluorine stands as a widespread building unit, demonstrating favorable pharmacological activity in numerous drugs and intermediates. In this study, we describe an Ir/f-diaphos catalyzed asymmetric hydrogenation of α-F-β-ketone amides...