Platinum Nanoparticles Regulated V2C MXene Nanoplatforms with NIR‐II Enhanced Nanozyme Effect for Photothermal and Chemodynamic Anti‐Infective Therapy

Abstract Given the challenge of multidrug resistance in antibiotics, non‐antibiotic–dependent antibacterial strategies show promise for anti‐infective therapy. V 2 C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V 2 C MXene's laser irradiation to the near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single‐effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) are attached to V 2 C, forming artificial nanoplatforms (Pt@V 2 C). Pt@V 2 C exhibits enhanced PCE (59.6%) and a longer irradiation laser (NIR‐II) due to the surface plasmon resonance effect of Pt NPs and V 2 C. Notably, Pt@V 2 C displays dual enzyme‐like activity with chemodynamic therapy (CDT) and NIR‐II enhanced dual enzyme‐like activity. The biocatalytic mechanism of Pt@V 2 C is elucidated using density functional theory. In an in vivo animal model, Pt@V 2 C effectively eliminates methicillin‐resistant Staphylococcus aureus from deep‐seated tissues in subcutaneous abscesses and bacterial keratitis environments, accelerating abscess resolution and promoting wound and cornea healing through the synergistic effects of PTT/CDT. Transcriptomic analysis reveals that Pt@V 2 C targets inflammatory pathways, providing insight into its therapeutic mechanism. This study presents a promising therapeutic approach involving hyperthermia‐amplified biocatalysis with Pt NPs and MXene nanocomposites.