染色质
组蛋白
表观遗传学
生物
乙酰化
组蛋白密码
表观遗传学
组蛋白修饰酶
计算生物学
化学生物学
细胞生物学
染色质重塑
DNA甲基化
遗传学
核小体
DNA
基因
基因表达
作者
Pauline Franz,Beat Fierz
标识
DOI:10.1016/j.jmb.2024.168442
摘要
Since Strahl and Allis proposed the "language of covalent histone modifications", a host of experimental studies have shed light on the different facets of chromatin regulation by epigenetic mechanisms. Initially proposed as a concept for controlling gene transcription, the regulation of deposition and removal of histone post-translational modifications (PTMs), such as acetylation, methylation, and phosphorylation, have been implicated in many chromatin regulation pathways. However, large PTMs such as ubiquitylation challenge research on many levels due to their chemical complexity. In recent years, chemical tools have been developed to generate chromatin in defined ubiquitylation states in vitro. Chemical biology approaches are now used to link specific histone ubiquitylation marks with downstream chromatin regulation events on the molecular level. Here, we want to highlight how chemical biology approaches have empowered the mechanistic study of chromatin ubiquitylation in the context of gene regulation and DNA repair with attention to future challenges.
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