自愈水凝胶
多酚
化学
组织修复
药理学
医学
生物医学工程
生物化学
高分子化学
抗氧化剂
作者
Wang Chun,Yi-Xin Qiao,Zhiqiang Huang,Zhen Zeng,Yan Pan,Xulin Hu,Zhihong Dong
出处
期刊:Journal of Biomaterials and Tissue Engineering
[American Scientific Publishers]
日期:2023-10-01
卷期号:13 (10): 953-967
标识
DOI:10.1166/jbt.2023.3339
摘要
As we all know, diabetes patients greatly decrease their quality of life and increase their economic burden. Tissue regeneration in diabetic wounds is a worldwide clinical challenge due to immune, genetic, and environmental factors. Severe infectious wounds in diabetic patients can potentially result in sepsis even amputation. Hence, it is necessary to use a rapid treatment strategy for effective anti-infection with hydrogel materials. Polyphenol polymers may quickly suppress reactive oxygen species of chronic inflammation for diabetic wounds. However, the instability of polyphenols reduces the rate of wound healing, using a hydrogel carrier as a carrier can improve the stability of polyphenolic compounds and control their release to accelerate wound healing. This review elaborates on diabetic wound pathogenesis, the therapeutic effect of polyphenolic hydrogel, including its preparation and stability, and the construction of the diabetes model, which provides a reference for the clinical treatment of diabetes.
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