脂肪组织
生物
白色脂肪组织
2型糖尿病
表型
人口
细胞外基质
基因表达
褐色脂肪组织
电池类型
内分泌学
细胞生物学
基因
核心
内科学
糖尿病
细胞
遗传学
医学
环境卫生
作者
Taylah L. Gaynor,Ian C. Hsu,Crisdion Krstevski,Gabriella E. Farrugia,Malathi S.I. Dona,Charles D. Cohen,Brian G. Drew,Alexander R. Pinto
标识
DOI:10.1101/2024.02.06.578860
摘要
Summary Excessive adipose tissue expansion is often linked with type-2 diabetes. Despite recent efforts mapping adipose tissue changes in obesity using single-cell omics, an understanding of cellular and gene expression changes in a model of type 2 diabetes, and the transcriptional circuitry controlling it, is still lacking. Here, we use single-nucleus RNA sequencing to analyse the remodelling of gonadal white and interscapular brown adipose tissue from female and male mice with or without diabetes. Analysis of 51,877 nuclei revealed altered phenotypes in every cell population in type 2 diabetes. This included an immunoregulatory response, and changes in extracellular matrix organisation, energy generation, and hormone stimuli. Key transcription factors were inferred as cell-specific and non-specific nodes controlling diabetes-linked phenotypes. Finally, female-to-male population heterogeneity and gene expression differences were observed. Here we provide a resource detailing how adipose tissue remodelling, and the molecular mechanisms governing it, may contribute to cardiometabolic disease.
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