糖酵解
生物化学
赖氨酸
瓦博格效应
厌氧糖酵解
化学
蛋白质组
癌细胞
醛缩酶A
乳酸
新陈代谢
酶
细胞生物学
生物
癌症
氨基酸
遗传学
细菌
作者
Zhe Cheng,Huichao Huang,Maoyu Li,Yongheng Chen
出处
期刊:iScience
[Elsevier]
日期:2023-12-06
卷期号:27 (1): 108645-108645
被引量:4
标识
DOI:10.1016/j.isci.2023.108645
摘要
Aerobic glycolysis is a pivotal hallmark of cancers, including colorectal cancer. Evidence shows glycolytic enzymes are regulated by post-translational modifications (PTMs), thereby affecting the Warburg effect and reprograming cancer metabolism. Lysine lactylation is a PTM reported in 2019 in histones. In this study, we identified protein lactylation in FHC cells and SW480 colon cancer cells through mass spectrometry. Totally, 637 lysine lactylation sites in 444 proteins were identified in FHC and SW480 cells. Lactylated proteins were enriched in the glycolysis pathway, and we identified lactylation sites in phosphofructokinase, platelet (PFKP) lysine 688 and aldolase A (ALDOA) lysine 147. We also showed that PFKP lactylation directly attenuated enzyme activity. Collectively, our study presented a resource to investigate proteome-wide lactylation in SW480 cells and found PFKP lactylation led to activity inhibition, indicating that lactic acid and lactylated PFKP may form a negative feedback pathway in glycolysis and lactic acid production.
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