寄主(生物学)
果蝇属(亚属)
微生物群
神经元
生物
神经科学
肠-脑轴
肠道微生物群
细胞生物学
生态学
生物信息学
遗传学
基因
作者
Jin Woo Lee,Kyung-Ah Lee,In-Hwan Jang,Ki-Bum Nam,Sunghee Kim,Minsoo Kyung,Kyu-Chan Cho,Jihoon Lee,Hye Jin You,Eun Kyoung Kim,Young Hoon Koh,Hansol Lee,Junsun Park,Soo‐Yeon Hwang,Youn Wook Chung,Choong‐Min Ryu,Youngjoo Kwon,Soung‐Hun Roh,Ji-Hwan Ryu,Won‐Jae Lee
标识
DOI:10.1038/s41467-025-57484-4
摘要
While it is now accepted that the microbiome has strong impacts on animal growth promotion, the exact mechanism has remained elusive. Here we show that microbiome-emitted scents contain volatile somatotrophic factors (VSFs), which promote host growth in an olfaction-independent manner in Drosophila. We found that inhaled VSFs are readily sensed by olfactory receptor 42b non-neuronally expressed in subsets of tracheal airway cells, enteroendocrine cells, and enterocytes. Olfaction-independent sensing of VSFs activates the airway-gut-brain axis by regulating Hippo, FGF and insulin-like growth factor signaling pathways, which are required for airway branching, organ oxygenation and body growth. We found that a mutant microbiome that did not produce (2R,3R)-2,3-butanediol failed to activate the airway-gut-brain axis for host growth. Importantly, forced inhalation of (2R,3R)-2,3-butanediol completely reversed these defects. Our discovery of contact-independent and olfaction-independent airborne interactions between host and microbiome provides a novel perspective on the role of the airway-gut-brain axis in microbiome-controlled host development.
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