材料科学
兴奋剂
放松(心理学)
光子
纳米技术
量子产额
纳米颗粒
双光子激发显微术
光电子学
光学
物理
心理学
社会心理学
荧光
作者
Miaozhuang Fan,Gang Feng,Lu Xia,Yibin Zhang,Maixian Liu,Zhengzheng Li,Yihang Jiang,Chengbin Yang,Wing‐Cheung Law,Ken‐Tye Yong,Yuanyuan Shen,Zhourui Xu,Gaixia Xu
标识
DOI:10.1002/adom.202300255
摘要
Abstract Aggregation‐induced emission luminogens (AIEgens) as a new class of optical probes for two‐photon imaging (2PI) have attracted extensive attention in the research community. However, their non‐radiative energy dissipation plays a non‐negligible role in energy consumption, thereby weakening their performance in 2PI. Exploration of a facile and general approach to control the energy relaxation pathways is thus a fascinating yet significantly challenging task. To address this concern, an organic doping method is proposed herein by using TPE‐Br as the doping AIEgen and MeOTTMN as the functional AIEgen. With increased amount of doping molecules, a steadily strengthened brightness (up to 29‐fold of quantum yield) is observed at the expense of reactive oxygen species production. Remarkably, an ultradeep imaging depth of 1000 µm in a mouse brain is realized via 2PI using the heavily organic‐doped AIEgen(ODA) nanoparticles (NPs). Such result is far superior to the imaging depth of 156 µm enabled by MeOTTMN NPs. The safe use of ODA NPs is further evaluated by in vitro and in vivo toxicity assessment. This study thus provides an attractive paradigm to control the energy relaxation of AIEgen NPs and maximize their performance in 2PI while circumventing the difficulties in molecular engineering.
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