Real‐time 3D MRI reconstruction from cine‐MRI using unsupervised network in MRI‐guided radiotherapy for liver cancer

Respiration has a major impact on the accuracy of radiation treatment for thorax and abdominal tumours. Instantaneous volumetric imaging could provide precise knowledge of tumour and normal organs' three-dimensional (3D) movement, which is the key to reducing the negative effect of breathing motion. Therefore, this study proposed a real-time 3D MRI reconstruction method from cine-MRI using an unsupervised network.Cine-MRI and setup 3D-MRI from eight patients with liver cancer were utilized to establish and validate the deep learning network for 3D-MRI reconstruction. Unlike previous methods that required 4D-MRI for network training, the proposed method utilized a reference 3D-MRI and cine-MRI to generate the training data. Then, a network was trained in an unsupervised manner to estimate the relationship between the cine-MRI acquired on coronal plane and deformation vector field (DVF) that describes the patient's breathing motion. After the training process, the coronal cine-MRI were inputted into the network, and the corresponding DVF was obtained. By wrapping the reference 3D-MRI with the generated DVF, the 3D-MRI could be reconstructed.The reconstructed 3D-MRI slices were compared with the corresponding phase-sorted cine-MRI using dice similarity coefficients (DSCs) of liver contours and blood vessel localization error. In all patients, the liver DSC had mean value >96.1% and standard deviation < 1.3%; the blood vessel localization error had mean value <2.6 mm, and standard deviation was <2.0 mm. Moreover, the time for 3D-MRI reconstruction was approximately 100 ms. These results indicated that the proposed method could accurately reconstruct the 3D-MRI in real time.The proposed method could accurately reconstruct the 3D-MRI from cine-MRI in real time. This method has great potential in improving the accuracy of radiotherapy for moving tumours.