脚手架
再生(生物学)
间充质干细胞
软骨
骨关节炎
生物医学工程
3D生物打印
关节软骨修复
组织工程
体内
关节软骨
材料科学
细胞生物学
医学
病理
解剖
生物
生物技术
替代医学
作者
Zijie Pei,Mingyang Gao,Junhui Xing,Changbao Wang,Piqian Zhao,Hongtao Zhang,Junle Qu
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2023-01-05
卷期号:9 (2)
标识
DOI:10.18063/ijb.v9i2.662
摘要
Cartilage damage is a common orthopedic disease, which can be caused by sports injury, obesity, joint wear, and aging, and cannot be repaired by itself. Surgical autologous osteochondral grafting is often required in deep osteochondral lesions to avoid the later progression of osteoarthritis. In this study, we fabricated a gelatin methacryloyl-marrow mesenchymal stem cells (GelMA-MSCs) scaffold by three-dimensional (3D) bioprinting. This bioink is capable of fast gel photocuring and spontaneous covalent cross-linking, which can maintain high viability of MSCs and provide a benign microenvironment to promote the interaction, migration, and proliferation of cells. In vivo experiments, further, proved that the 3D bioprinting scaffold can promote the regeneration of cartilage collagen fibers and have a remarkable effect on cartilage repair of rabbit cartilage injury model, which may represent a general and versatile strategy for precise engineering of cartilage regeneration system.
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