立体中心
反演(地质)
对映体
组合化学
化学
药品
非甾体
立体化学
药理学
对映选择合成
有机化学
生物
催化作用
构造盆地
古生物学
作者
Hassan Y. Aboul‐Enein,Valliappan Kannappan,Selvakumar Kanthiah
出处
期刊:Combinatorial Chemistry & High Throughput Screening
[Bentham Science]
日期:2023-01-03
卷期号:26 (15): 2577-2582
被引量:3
标识
DOI:10.2174/1386207326666230102123655
摘要
Abstract: 2-Arylpropionic acid nonsteroidal anti-inflammatory drugs (NSAIDs) provide one of the most demonstrated pharmaceutical examples of chiral inversion. Chiral inversion depends on various factors (viz. biological-, solvent-, light-, temperature-induced, etc.) and the energy barrier associated with the stereogenic element present in the chiral molecule. The pharmacological properties of chiral drugs depend on the activity of one enantiomer or both the enantiomers targeting different biological targets. Consequently, chiral inversion can alter the biological activities of the pharmaceutical drug. Hence a better understanding of chiral inversion, factors facilitating such inversion, and the tools employed to determine chiral inversion are of great significance from a pharmacological and toxicological perspective.
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