ALFF response interaction with learning during feedback in individuals with multiple sclerosis

相关性 医学 多发性硬化 联想(心理学) 听力学 大脑活动与冥想 静息状态功能磁共振成像 神经科学 丘脑 心理学 脑电图 精神科 几何学 数学 心理治疗师
作者
Ekaterina Dobryakova,Rakibul Hafiz,Olesya Iosipchuk,Joshua Sandry,Bharat B. Biswal
出处
期刊:Multiple sclerosis and related disorders [Elsevier BV]
卷期号:70: 104510-104510
标识
DOI:10.1016/j.msard.2023.104510
摘要

Amplitude of low-frequency fluctuations (ALFF) is defined as changes of BOLD signal during resting state (RS) brain activity. Previous studies identified differences in RS activation between healthy and multiple sclerosis (MS) participants. However, no research has investigated the relationship between ALFF and learning in MS. We thus examine this here. Twenty-five MS and nineteen healthy participants performed a paired-associate word learning task where participants were presented with extrinsic or intrinsic performance feedback. Compared to healthy participants, MS participants showed higher local brain activation in the right thalamus. We also observed a positive correlation in the MS group between ALFF and extrinsic feedback within the left inferior frontal gyrus, and within the left superior temporal gyrus in association with intrinsic feedback. Healthy participants showed a positive correlation in the right fusiform gyrus between ALFF and extrinsic feedback. Findings suggest that while MS participants do not show a feedback learning impairment compared to the healthy participants, ALFF differences might suggest a general maladaptive pattern of task unrelated thalamic activation and adaptive activation in frontal and temporal regions. Results indicate that ALFF can be successfully used at capturing pathophysiological changes in local brain activation in MS in association with learning through feedback.
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