RAC1
罗亚
细胞生物学
生物
Rac-GTP结合蛋白
运动性
支架蛋白
脚手架
细胞迁移
信号转导
细胞
生物化学
医学
生物医学工程
作者
Darren Chen Pei Wong,Catherine Pan,Shi Yin Er,T. Thivakar,Tan Zi Yi Rachel,Sock Hong Seah,Pei Jou Chua,Tingting Jiang,Ti Weng Chew,Parthiv Kant Chaudhuri,Somsubhro Mukherjee,Agus Salim,Thike Aye Aye,Cheng-Gee Koh,Chwee Teck Lim,Puay Hoon Tan,Boon‐Huat Bay,Anne J. Ridley,Boon Chuan Low
标识
DOI：10.1091/mbc.e21-03-0099
摘要
How the activities of Rho and Rac are coordinated through their GEF and GAP remains unclear. The prometastatic RhoGAP, BPGAP1, recruits the RacGEF Vav1 to activate Rac1 while it down-regulates the local RhoA activity that in turns influences Rac1 activation by Vav1. BPGAP1 acts as a scaffold to synchronize Rho and Rac signaling in cell motility.
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