The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders—An Evidence Mapping Based on Quantified Evidence

自闭症谱系障碍 双相情感障碍 精神分裂症(面向对象编程) 精神科 焦虑 医学 重性抑郁障碍 广泛性焦虑症 系统回顾 疾病 注意缺陷多动障碍 科克伦图书馆 临床心理学 荟萃分析 自闭症 内科学 心情 梅德林 生物 生物化学
作者
Yaning Zang,Xigui Lai,Conghui Li,Dongfang Ding,Ying Wang,Yi Zhu
出处
期刊:Mediators of Inflammation [Hindawi Publishing Corporation]
卷期号:2023: 1-16 被引量:26
标识
DOI:10.1155/2023/5127157
摘要

Background and Object. There is a growing body of evidence highlighting the significant role of gut microbiota in various neurological and psychiatric disorders. We performed an evidence mapping to review the association between different microbiota and these disorders and assessed the strength of evidence for these associations. Methods. We searched PubMed, Cochrane Library, and Epistemonikos to identify systematic reviews and meta-analysis (SRs). We searched for neurological diseases and psychiatric disorders, including Alzheimer’s disease (AD), attention deficit hyperactivity disorder (ADHD), amyotrophic lateral sclerosis (ALS), autism spectrum disorder (ASD), anorexia nervosa (AN), bipolar disorder (BD), eating disorder (ED), generalized anxiety disorder (GAD), major depressive disorder (MDD), multiple sclerosis (MS), obsessive compulsive disorder (OCD), Parkinson’s disease (PD), posttraumatic stress disorder (PTSD), spinal cord injury (SCI), schizophrenia, and stroke. We used A Measurement Tool to Assess Systematic Reviews (AMSTAR-2) to evaluate the quality of included SRs. We also created an evidence map showing the role of gut microbiota in neurological diseases and the certainty of the evidence. Results. In total, 42 studies were included in this evidence mapping. Most findings were obtained from observational studies. According to the AMSTAR-2 assessment, 21 SRs scored “critically low” in terms of methodological quality, 16 SR scored “low,” and 5 SR scored “moderate.” A total of 15 diseases have been investigated for the potential association between gut microbiome alpha diversity and disease, with the Shannon index and Simpson index being the most widely studied. A total of 12 diseases were investigated for potential link between beta diversity and disease. At the phylum level, Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia were more researched. At the genus level, Prevotella, Coprococcus, Parabacteroides, Phascolarctobacterium, Escherichia Shigella, Alistipes, Sutteralla, Veillonella, Odoribacter, Faecalibacterium, Bacteroides, Bifidobacterium, Dialister, and Blautia were more researched. Some diseases have been found to have specific flora changes, and some diseases have been found to have common intestinal microbiological changes. Conclusion. We found varied levels of evidence for the associations between gut microbiota and neurological diseases; some gut microbiota increased the risk of neurological diseases, whereas others showed evidence of benefit that gut microbiota might be promising therapeutic targets for such diseases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
asd113发布了新的文献求助10
2秒前
美满的小蘑菇完成签到 ,获得积分10
2秒前
自然白安完成签到 ,获得积分10
8秒前
量子星尘发布了新的文献求助10
11秒前
等待小鸽子完成签到 ,获得积分10
13秒前
龙虾发票完成签到,获得积分10
20秒前
小康学弟完成签到 ,获得积分10
20秒前
了0完成签到 ,获得积分10
20秒前
慕青应助科研通管家采纳,获得10
23秒前
彭于晏应助科研通管家采纳,获得30
23秒前
毛豆爸爸应助科研通管家采纳,获得20
23秒前
林利芳完成签到 ,获得积分0
24秒前
JaneChen完成签到 ,获得积分10
26秒前
健壮惋清完成签到 ,获得积分10
26秒前
27秒前
gabee完成签到 ,获得积分10
31秒前
liang19640908完成签到 ,获得积分10
34秒前
奋斗的雪曼完成签到 ,获得积分10
40秒前
粗心的飞槐完成签到 ,获得积分10
40秒前
LELE完成签到 ,获得积分10
47秒前
了0完成签到 ,获得积分10
48秒前
apocalypse完成签到 ,获得积分10
53秒前
guhao完成签到 ,获得积分10
54秒前
指导灰完成签到 ,获得积分10
54秒前
善良的火完成签到 ,获得积分10
1分钟前
优雅夕阳完成签到 ,获得积分10
1分钟前
Jasper应助光亮的自行车采纳,获得10
1分钟前
miki完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
糖宝完成签到 ,获得积分10
1分钟前
KX2024完成签到,获得积分10
1分钟前
松松发布了新的文献求助20
1分钟前
nusiew完成签到,获得积分10
1分钟前
huiluowork完成签到 ,获得积分10
1分钟前
陶醉的翠霜完成签到 ,获得积分10
1分钟前
1分钟前
冷静如松完成签到 ,获得积分10
1分钟前
1分钟前
浮云完成签到 ,获得积分10
1分钟前
屈岂愈完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022