糖肽
化学
抗生素
糖肽抗生素
组合化学
纳米颗粒
分子识别
有机化学
纳米技术
万古霉素
细菌
生物化学
材料科学
分子
金黄色葡萄球菌
生物
遗传学
作者
Dongfeng Hong,Caijian Nie,Liujing Gao,Бо Лю
出处
期刊:Analytical Methods
[The Royal Society of Chemistry]
日期:2024-01-01
卷期号:16 (27): 4524-4533
摘要
Taking into account the drug resistance of antibiotics, teicoplanin has been banned in the veterinary field. Also, it brings threat to people's health when they eat foods containing teicoplanin residue. In addition, the abuse of teicoplanin in humans and food animals also poses a potential risk to water. Therefore, it is crucial to purify teicoplanin from food before quantifying its amount. In this study, researchers employed boronate affinity-based controlled oriented surface imprinting technique to produce molecularly imprinted polymers (MIPs) for the isolation of teicoplanin. The 3-fluoro-4-formylphenylboronic acid-functionalized silica nanoparticle substrate was first used as the supporting material for immobilizing teicoplanin. Next, the substrate surface was coated with an imprinting coating whose thickness could be controlled, produced through the self-copolymerization of dopamine and
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