光热治疗
生物医学中的光声成像
材料科学
纳米棒
吸收(声学)
胶体金
近红外光谱
光声效应
纳米技术
纳米颗粒
对比度(视觉)
分子成像
光学
体内
物理
复合材料
生物技术
生物
作者
Myeongsoo Kim,Kelsey P. Kubelick,Don VanderLaan,David Qin,Jeungyoon Lee,Anamik Jhunjhunwala,Melissa Cadena,Robert J. Nikolai,Jinhwan Kim,Stanislav Emelianov
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-05-15
卷期号:24 (24): 7202-7210
被引量:2
标识
DOI:10.1021/acs.nanolett.4c00992
摘要
Structural parameters play a crucial role in determining the electromagnetic and thermal responses of gold nanoconstructs (GNCs) at near-infrared (NIR) wavelengths. Therefore, developing GNCs for reliable, high-contrast photoacoustic imaging has been focused on adjusting structural parameters to achieve robust NIR light absorption with photostability. In this study, we introduce an efficient photoacoustic imaging contrast agent: gold sphere chains (GSCs) consisting of plasmonically coupled gold nanospheres. The chain geometry results in enhanced photoacoustic signal generation originating from outstanding photothermal characteristics compared to traditional gold contrast agents, such as gold nanorods. Furthermore, the GSCs produce consistent photoacoustic signals at laser fluences within the limits set by the American National Standards Institute. The exceptional photoacoustic response of GSCs allows for high-contrast photoacoustic imaging over multiple imaging sessions. Finally, we demonstrate the utility of our GSCs for molecular photoacoustic cancer imaging, both in vitro and in vivo, through the integration of a tumor-targeting moiety.
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