The Role of Cytokines in Cutaneous T Cell Lymphoma: A Focus on the State of the Art and Possible Therapeutic Targets

蕈样真菌病 免疫学 肿瘤微环境 疾病 皮肤T细胞淋巴瘤 免疫系统 医学 细胞因子 免疫疗法 淋巴瘤 T细胞 癌症研究 病理
作者
Alba Guglielmo,Corrado Zengarini,Claudio Agostinelli,Giovanna Motta,Elena Sabattini,Alessandro Pileri
出处
期刊:Cells [MDPI AG]
卷期号:13 (7): 584-584
标识
DOI:10.3390/cells13070584
摘要

Cutaneous T cell lymphomas (CTCLs), encompassing mycosis fungoides (MF) and Sézary syndrome (SS), present a complex landscape influenced by cytokines and cellular responses. In this work, the intricate relationship between these inflammatory proteins and disease pathogenesis is examined, focusing on what is known at the clinical and therapeutic levels regarding the most well-known inflammatory mediators. An in-depth look is given to their possible alterations caused by novel immunomodulatory drugs and how they may alter disease progression. From this narrative review of the actual scientific landscape, Interferon-gamma (IFN-γ) emerges as a central player, demonstrating a dual role in both promoting and inhibiting cancer immunity, but the work navigates through all the major interleukins known in inflammatory environments. Immunotherapeutic perspectives are elucidated, highlighting the crucial role of the cutaneous microenvironment in shaping dysfunctional cell trafficking, antitumor immunity, and angiogenesis in MF, showcasing advancements in understanding and targeting the immune phenotype in CTCL. In summary, this manuscript aims to comprehensively explore the multifaceted aspects of CTCL, from the immunopathogenesis and cytokine dynamics centred around TNF-α and IFN-γ to evolving therapeutic modalities. Including all the major known and studied cytokines in this analysis broadens our understanding of the intricate interplay influencing CTCL, paving the way for improved management of this complex lymphoma.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
星月发布了新的文献求助10
刚刚
lr发布了新的文献求助10
1秒前
3秒前
浮三白发布了新的文献求助10
3秒前
5秒前
夏夏发布了新的文献求助10
8秒前
再也不拖发布了新的文献求助10
8秒前
小骁同学完成签到,获得积分10
9秒前
元谷雪应助姚美阁采纳,获得10
10秒前
rainbow5432完成签到 ,获得积分10
10秒前
张阳完成签到,获得积分10
12秒前
仁爱的绮兰完成签到,获得积分20
12秒前
科研通AI2S应助科研通管家采纳,获得10
14秒前
SciGPT应助科研通管家采纳,获得10
14秒前
隐形曼青应助科研通管家采纳,获得10
15秒前
英姑应助科研通管家采纳,获得10
15秒前
隐形曼青应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
15秒前
15秒前
麻薯头头发布了新的文献求助10
15秒前
cnkly完成签到,获得积分10
17秒前
Jasper应助一定要早睡采纳,获得10
18秒前
18秒前
19秒前
乾坤完成签到,获得积分10
20秒前
21秒前
21秒前
星月完成签到,获得积分10
23秒前
24秒前
25秒前
jiudai完成签到 ,获得积分10
26秒前
11完成签到,获得积分10
26秒前
爱你的心满满完成签到 ,获得积分10
29秒前
29秒前
支颐完成签到,获得积分10
30秒前
32秒前
叫什么好呢完成签到,获得积分20
33秒前
11发布了新的文献求助10
35秒前
高分求助中
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137706
求助须知:如何正确求助?哪些是违规求助? 2788609
关于积分的说明 7787778
捐赠科研通 2444975
什么是DOI,文献DOI怎么找? 1300139
科研通“疑难数据库(出版商)”最低求助积分说明 625814
版权声明 601043