EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer. Part II—2024 Update: Treatment of Relapsing and Metastatic Prostate Cancer

医学 前列腺癌 指南 恩扎鲁胺 肿瘤科 放射治疗 内科学 妇科 癌症 病理 雄激素受体
作者
Derya Tilki,Roderick C.N. van den Bergh,Erik Briers,Thomas Van den Broeck,Oliver Brunckhorst,Julie Darraugh,Daniel Eberli,Gert De Meerleer,Maria De Santis,Andrea Farolfi,Giorgio Gandaglia,Silke Gillessen,Nikolaos Grivas,Ann Henry,Michael Lardas,Geert J.L.H. van Leenders,Matthew Liew,Estefanía Linares,Jan Oldenburg,Inge M. van Oort
出处
期刊:European Urology [Elsevier BV]
卷期号:86 (2): 164-182 被引量:109
标识
DOI:10.1016/j.eururo.2024.04.010
摘要

The European Association of Urology (EAU)-European Association of Nuclear Medicine (EANM)-European Society for Radiotherapy and Oncology (ESTRO)-European Society of Urogenital Radiology (ESUR)-International Society of Urological Pathology (ISUP)-International Society of Geriatric Oncology (SIOG) guidelines on the treatment of relapsing, metastatic, and castration-resistant prostate cancer (PCa) have been updated. Here we provide a summary of the 2024 guidelines. The panel performed a literature review of new data, covering the time frame between 2020 and 2023. The guidelines were updated and a strength rating for each recommendation was added on the basis of a systematic review of the evidence. Risk stratification for relapsing PCa after primary therapy may guide salvage therapy decisions. New treatment options, such as androgen receptor–targeted agents (ARTAs), ARTA + chemotherapy combinations, PARP inhibitors and their combinations, and prostate-specific membrane antigen–based therapy have become available for men with metastatic PCa. Evidence for relapsing, metastatic, and castration-resistant PCa is evolving rapidly. These guidelines reflect the multidisciplinary nature of PCa management. The full version is available online (http://uroweb.org/guideline/ prostate-cancer/). This article summarises the 2024 guidelines for the treatment of relapsing, metastatic, and castration-resistant prostate cancer. These guidelines are based on evidence and guide doctors in discussing treatment decisions with their patients. The guidelines are updated every year.
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