作者
Joanna Japhet Tibenda,Yong Du,Yi Nan,Sheng‐Chao Huang,Gang Chen,Ning Na,Xiaoyan Li,Yi Yang,Ling Yuan
摘要
Astragalus membranaceus (AM) is an outstanding traditional medicinal herb that has been highly utilized for many decades in China, mainly as an adaptogen. Several medicinal functions have been associated with the components of astragalus, such as antitumor, anti-inflammatory, immune-enhancing, antioxidative, neuroprotective, and cardioprotective functions. In addition to providing future ideas on the pharmacological effects of Astragalus membranaceus in the treatment of gastric cancer, this review aims to elucidate the active components of Astragalus membranaceus and its antitumor effects in gastric cancer (GC), as well as highlight the existing experimental studies on the mechanism of AM in gastric cancer. Literature publications relevant to the aim of the study were screened from Science Direct, PubMed, Web of Science, and Google Scholar. "Astragalus Mongholicus," "Astragalus Mongholicus, Gastric Cancer," "Astragalus Polysaccharides, Gastric Cancer," "Astragalus Saponins, Gastric Cancer," and "Flavonoids of Astragalus," were the key terms used. Studies showed that the mechanism of action of Astragalus membranaceus in gastric cancer mainly includes suppression of cellular migration, proliferation, and invasion of GC cells. Furthermore, AM promotes cell cycle arrest and apoptosis by regulating several intracellular signaling pathways involved mainly in the immune system and inflammation. The main active ingredients of AM, such as Astragalus polysaccharide, Astragaloside IV, and flavonoids like Calycosin, play a major role in attenuating gastric cancer. The compounds were found to possess potent antitumor effects against GC and have to be further evaluated. AM is also a potential adjuvant chemotherapy agent.