记忆B细胞
抗原
生物
抗体
幼稚B细胞
B细胞
病毒学
记忆T细胞
佐剂
免疫系统
接种疫苗
T细胞
免疫学
抗原提呈细胞
作者
Lilit Grigoryan,Yupeng Feng,Lorenza Bellusci,Lilin Lai,Bushra Wali,Madison Ellis,Meng Yuan,Prabhu S. Arunachalam,Mengyun Hu,Sangeeta Kowli,Sheena Gupta,Sofia Maysel-Auslender,Holden T. Maecker,Hady Samaha,Nadine Rouphael,Ian A. Wilson,Alberto Moreno,Mehul S. Suthar,Surender Khurana,Stéphane Pillet,Nathalie Charland,Brian J. Ward,Bali Pulendran
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2024-04-05
卷期号:9 (94)
被引量:6
标识
DOI:10.1126/sciimmunol.adi8039
摘要
Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is due to the generation of antigen-specific B cell clones with distinct specificities or the maturation of memory B cell clones that produce broadly cross-reactive antibodies is unknown. Here, we longitudinally analyzed immune responses in healthy adults after two-dose vaccination with either a virus-like particle COVID-19 vaccine (CoVLP), CoVLP adjuvanted with AS03 (CoVLP+AS03), or a messenger RNA vaccination (mRNA-1273). CoVLP+AS03 enhanced the magnitude and durability of circulating antibodies and antigen-specific CD4 + T cell and memory B cell responses. Antigen-specific CD4 + T cells in the CoVLP+AS03 group at day 42 correlated with antigen-specific memory B cells at 6 months. CoVLP+AS03 induced memory B cell responses, which accumulated somatic hypermutations over 6 months, resulting in enhanced neutralization breadth of monoclonal antibodies. Furthermore, the fraction of broadly neutralizing antibodies encoded by memory B cells increased between day 42 and 6 months. These results indicate that AS03 enhances the antigenic breadth of B cell memory at the clonal level and induces progressive maturation of the B cell response.
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