溶瘤病毒
丙烯酰胺
病毒
生物
病毒学
化学
癌症研究
材料科学
共聚物
聚合物
有机化学
作者
Gong Chen,Yuan Yuan,Ying Li,Qianyuan He,Zizhen Qin,Han Hu,Congcong Gao,Zushun Xu,Qi Xu,Qinglei Gao,Fei Li
摘要
Oncolytic virus ablation of tumor cells has the advantages of high tumor selectivity, strong immunogenicity, and low side effects. However, the recognition and clearance of oncolytic viruses by the immune system are the main factors limiting their anti-tumor efficiency. As a highly biosafe and highly modifiable oncolytic virus vector, acrylamide can improve the long-term circulation of oncolytic viruses. Still, it is limited in its uptake efficiency by tumor cells. Herein, we constructed an
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