立体光刻
聚己内酯
组织工程
生物相容性
傅里叶变换红外光谱
丙烯酸酯
透皮
生物医学工程
化学
光引发剂
化学工程
纳米技术
材料科学
复合材料
共聚物
有机化学
聚合物
工程类
医学
单体
药理学
作者
Deniz Sakarya,F. Baris Barlas,Yeşim Müge Şahin,Sevil Yücel
出处
期刊:Main Group Chemistry
[IOS Press]
日期:2024-04-30
卷期号:23 (3): 271-282
被引量:1
摘要
Recently, advancements in fabrication technology have brought a new aspect to the field of tissue engineering. By utilizing advanced techniques in 3D manufacturing and biomaterials, scientists have successfully created tissue engineering scaffolds with complex three-dimensional structures and customized chemical compositions that closely mimic the natural environment of living tissues. These methodologies show potential not only for developing therapies that restore lost tissue function but also for creating in vitro models that replicate living tissue. The current investigation involved the synthesis of methacrylated polycaprolactone (PCLMA) by incorporating methacryloyl chloride (Meth-Cl) into polycaprolactone (PCL) with a molecular weight of 80,000 Da. Afterwards, PCLMA was subjected to crosslinking with glycerol acrylate (GA) and, by utilizing Diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide (TPO) as a photoinitiator, achieved the three-dimensional (3D) printing of tissue materials using Stereolithography (SLA). Analytical techniques included nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Cell viability was investigated using Human Osteoblast (HOB) cells. The biocompatibility of glycerol acrylate (GA) crosslinked polymethacrylated polycaprolactone (PCLMA) was confirmed using cell viability experiments. Overall, the GA-crosslinked PCLMA bioresin, particularly PCLMA-8, shows promise for further use in tissue engineering applications.
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