Two-component macrophage model for active phagocytosis with pseudopod formation

吞噬作用 伪足 细胞骨架 细胞生物学 巨噬细胞 生物物理学 肌动蛋白 生物 化学 细胞 生物化学 体外
作者
Shuo Wang,Shuhao Ma,He Li,Ming Dao,Xuejin Li,George Em Karniadakis
出处
期刊:Biophysical Journal [Elsevier BV]
卷期号:123 (9): 1069-1084 被引量:3
标识
DOI:10.1016/j.bpj.2024.03.026
摘要

Macrophage phagocytosis is critical for the immune response, homeostasis regulation, and tissue repair. This intricate process involves complex changes in cell morphology, cytoskeletal reorganization, and various receptor-ligand interactions controlled by mechanical constraints. However, there is a lack of comprehensive theoretical and computational models that investigate the mechanical process of phagocytosis in the context of cytoskeletal rearrangement. To address this issue, we propose a novel coarse-grained mesoscopic model that integrates a fluid-like cell membrane and a cytoskeletal network to study the dynamic phagocytosis process. The growth of actin filaments results in the formation of long and thin pseudopods, and the initial cytoskeleton can be disassembled upon target entry and reconstructed after phagocytosis. Through dynamic changes in the cytoskeleton, our macrophage model achieves active phagocytosis by forming a phagocytic cup utilizing pseudopods in two distinct ways. We have developed a new algorithm for modifying membrane area to prevent membrane rupture and ensure sufficient surface area during phagocytosis. In addition, the bending modulus, shear stiffness, and cortical tension of the macrophage model are investigated through computation of the axial force for the tubular structure and micropipette aspiration. With this model, we simulate active phagocytosis at the cytoskeletal level and investigate the mechanical process during the dynamic interplay between macrophage and target particles.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
英姑应助summer3moon采纳,获得10
刚刚
在水一方应助灵巧一笑采纳,获得10
刚刚
ranj驳回了华仔应助
1秒前
1秒前
科研通AI2S应助椰叶采纳,获得10
1秒前
搜集达人应助DONGmumu采纳,获得10
1秒前
FashionBoy应助9℃采纳,获得10
2秒前
jiejie发布了新的文献求助10
2秒前
2秒前
善学以致用应助AA采纳,获得10
2秒前
阿姜姜姜姜应助yu采纳,获得10
3秒前
zzbyxh驳回了水木应助
3秒前
透明人完成签到,获得积分10
3秒前
温婉的从寒完成签到,获得积分10
3秒前
4秒前
明理鱼完成签到,获得积分10
4秒前
随心完成签到,获得积分10
4秒前
pluto应助zm采纳,获得10
5秒前
5秒前
欧皇降霖完成签到 ,获得积分10
6秒前
子乔发布了新的文献求助20
6秒前
童绾绾发布了新的文献求助10
6秒前
6秒前
7秒前
透明人发布了新的文献求助10
7秒前
h7nho发布了新的文献求助10
7秒前
7秒前
xiaoting应助largedream采纳,获得30
8秒前
8秒前
8秒前
8秒前
顾矜应助Dr.c采纳,获得10
9秒前
9秒前
橙子皮发布了新的文献求助10
9秒前
hh完成签到 ,获得积分10
9秒前
10秒前
缓慢如南应助yu采纳,获得10
10秒前
10秒前
鹿子轩发布了新的文献求助10
10秒前
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970949
求助须知:如何正确求助?哪些是违规求助? 3515634
关于积分的说明 11179061
捐赠科研通 3250769
什么是DOI,文献DOI怎么找? 1795474
邀请新用户注册赠送积分活动 875831
科研通“疑难数据库(出版商)”最低求助积分说明 805188