多重耐药
微生物学
抗菌剂
生物
营养不良
金黄色葡萄球菌
免疫学
耐甲氧西林金黄色葡萄球菌
吞噬作用
抗生素
医学
细菌
内科学
遗传学
作者
Keenan A. Lacey,Adam M. Pickrum,Sandra González,Eric Bartnicki,Ashley Castellaw,Tori C. Rodrick,Drew R. Jones,Kamal M. Khanna,Victor J. Torres
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-07-26
卷期号:10 (30)
标识
DOI:10.1126/sciadv.adi7438
摘要
Dehydration and malnutrition are common and often underdiagnosed in hospital settings. Multidrug-resistant bacterial infections result in more than 35,000 deaths a year in nosocomial patients. The effect of temporal dietary and water restriction (DWR) on susceptibility to multidrug-resistant pathogens is unknown. We report that DWR markedly increased susceptibility to systemic infection by ESKAPE pathogens. Using a murine bloodstream model of methicillin-resistant Staphylococcus aureus infection, we show that DWR leads to significantly increased mortality and morbidity. DWR causes increased bacterial burden, severe pathology, and increased numbers of phagocytes in the kidney. DWR appears to alter the functionality of these phagocytes and is therefore unable to control infection. Mechanistically, we show that DWR impairs the ability of macrophages to phagocytose multiple bacterial pathogens and efferocytose apoptotic neutrophils. Together, this work highlights the crucial impact that diet and hydration play in protecting against infection.
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