上睑下垂
人参
肝损伤
肠道菌群
医学
细胞凋亡
人参皂甙
半胱氨酸蛋白酶
药理学
中医药
炎症
生物
程序性细胞死亡
免疫学
炎症体
病理
生物化学
替代医学
作者
Xu-fei Gao,Baoyu Ji,Jun-Jie Zhang,Zi Wang,Shucui Jiang,Jun‐nan Hu,Xiao‐Jie Gong,Jing-Tian Zhang,Ivan Stève Nguepi Tsopmejio,Wei Li
标识
DOI:10.1142/s0192415x24500563
摘要
Aging is an irresistible natural law of the progressive decline of body molecules, organs, and overall function with the passage of time, resulting in eventual death. World Health Organization data show that aging is correlated with a wide range of common chronic diseases in the elderly, and is an essential driver of many diseases. Panax Ginseng C.A Meyer is an ancient herbal medicine, which has an effect of “long service, light weight, and longevity” recorded in the ancient Chinese medicine book “Compendium of Materia Medica.” Ginsenoside Rg2, the main active ingredient of ginseng, also exerts a marked effect on the treatment of liver injury. However, it remains unclear whether Rg2 has the potential to ameliorate aging-induced liver injury. Hence, exploring the hepatoprotective properties of Rg2 and its possible molecular mechanism by Senescence Accelerate Mouse Prone 8 (SAMP8) and gut microbiota. Our study demonstrated that Rg2 can inhibit pyroptosis and apoptosis through caspase 8, and regulate the gut-liver axis to alleviate liver inflammation by changing the composition of gut microbiota, thus improving aging-induced liver injury. These findings provide theoretical support for the pharmacological effects of ginsenosides in delaying aging-induced liver injury.
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