结直肠癌
明星(博弈论)
医学
生物
癌症
内科学
物理
天体物理学
作者
Yuanzhi Zhou,Chengyan Wei,Yuqi Xu,Jingjing Wang,Chunwei Zhang,Yong Jin
出处
期刊:Current Cancer Drug Targets
[Bentham Science]
日期:2024-08-06
卷期号:24
标识
DOI:10.2174/0115680096323472240710101854
摘要
Colorectal cancer (CRC) is currently the third most common malignancy world-wide, with an increasing mortality rate and treatment resistance. Due to the lack of effective biomarkers and therapeutic targets, the early diagnosis and treatment of colorectal cancer re-main suboptimal. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with co-valent closed-loop structures that are well stabilized and conserved and are involved in multi-ple pathological conditions in humans. CircRNAs have been identified to be enriched and sta-ble in exosomes. In addition, there is growing proof that exosomal circRNAs that have been identified as oncogenes or tumor suppressors regulate CRC growth, migration, and sensitivity to radiotherapy and chemotherapy. Exosomal circRNAs represent promising candidates as di-agnostic biomarkers and anti-tumor targets. In this article, we explore recent studies on exo-somal circRNAs in CRC and describe their biological functions in colorectal cancer develop-ment, illustrating their potential as biomarkers and targeted therapeutic capabilities.
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