Biodegradable Persistent ROS-Generating Nanosonosensitizers for Enhanced Synergistic Cancer Therapy by Inducing Cascaded Oxidative Stress

Sonodynamic therapy (SDT) is gaining popularity in cancer treatment due to its superior controllability and high tissue permeability. Nonetheless, the efficacy of SDT is severely diminished by the transient generation of limited reactive oxygen species (ROS). Herein, we introduce an acid-activated nanosonosensitizer, CaO