Abstract Electronic skin is increasingly receiving tremendous attention for its potential applications in medical rehabilitation and human‐machine interaction. However, the trade‐off between detection range and sensitivity of e‐skin has not been well addressed, although various strategies have been proposed. Interlocked microridges between the epidermis and dermis can effectively transfer stress to mechanoreceptors, allowing human skin to exhibit excellent sensitivity even upon both subtle and large external stimuli. Herein, inspired by human skin, a novel bionic e‐skin is developed in which interlocked microridges are introduced between the sensitive layer and interdigitated electrode. Thanks to the interlocked microridges, excellent compression capability and remarkable change of contact area between sensitive layer and interdigitated electrode can be achieved and the e‐skin exhibits an ultrahigh sensitivity (≈1502.5 kPa −1 ), excellent durability (10 000 cycles), a short response time (10 ms) as well as a wide detection range (≈160 kPa). Moreover, due to the effective transmission of external stress from a sensitive layer to an interdigitated electrode, such bionic e‐skin has ability to detect a wide range of human vital signs and vibrations caused by sound waves. Such facile preparation of bionic interlocked microridges opens a new pathway to achieve high‐performance e‐skins and extend their application prospects in future wearable intelligent systems.