GLP-1 Receptor Agonists Confer No Increased Rates of IBD Exacerbation Among Patients With IBD

医学 兴奋剂 恶化 胰高血糖素样肽1受体 内科学 炎症性肠病 药方 克罗恩病 受体 胃肠病学 内分泌学 疾病 药理学
作者
Irving Levine,Shaina Sekhri,William Schreiber-Stainthorp,Brandon Locke,Olivia Delau,M. F. S. El-Hawary,Krutika Pandit,Xucong Meng,Jordan E. Axelrad
出处
期刊:Inflammatory Bowel Diseases [Oxford University Press]
被引量:1
标识
DOI:10.1093/ibd/izae250
摘要

Abstract Background In patients with inflammatory bowel disease (IBD), multimorbidity with obesity and type 2 diabetes is common and increasing. Glucagon-like peptide 1 (GLP-1) receptor agonists are increasingly being prescribed for patients with IBD, yet their impact on patients with IBD is largely unknown. We aimed to assess the impact of GLP-1 receptor agonists on the course of IBD. Methods We identified all IBD patients prescribed GLP-1 receptor agonists at a large academic healthcare network between 2009 and 2023. We analyzed demographics and IBD characteristics in the year pre- and post–GLP-1 receptor agonist prescription and matched them to non-IBD controls. Our primary outcome was IBD exacerbation in the year following GLP-1 receptor agonist initiation, measured as a composite of IBD-related hospitalization, corticosteroid prescription, medication escalation or changes, or IBD-related surgery. Secondary outcomes included change in metabolic risk factors. Results Overall, 224 patients met inclusion criteria. At GLP-1 receptor agonist initiation, the median age was 54 years, 63% were female, 77% were White, and median BMI was 33.2 kg/m2. Compared to the 12-month period prior to GLP-1 receptor agonist initiation, in the 12 months post–GLP-1 receptor agonist initiation, there was no change in rates of IBD exacerbation, IBD-related hospitalization, steroids prescription, medication escalation or changes, or IBD-related surgery. There was a significant decrease in BMI in the year following GLP-1 receptor agonist initiation (median BMI 33.5 vs 31.6 kg/m2, P < .01), with rates of decrease comparable to non-IBD matched controls. Conclusions In patients with IBD, GLP-1 receptor agonists are effective for weight loss and associated with few episodes of disease exacerbation.
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