失调
类风湿性关节炎
免疫学
微生物群
发病机制
趋化因子
免疫系统
自身免疫性疾病
医学
肠道菌群
肠道微生物群
炎症
疾病
生物
生物信息学
内科学
抗体
作者
Estera Bakinowska,Wiktoria Stańska,Kajetan Kiełbowski,Agata Szwedkowicz,Dominika Boboryko,Andrzej Pawlik
出处
期刊:Nutrients
[MDPI AG]
日期:2024-09-23
卷期号:16 (18): 3215-3215
摘要
Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease. The pathogenesis of RA is complex and involves interactions between articular cells, such as fibroblast-like synoviocytes, and immune cells. These cells secrete pro-inflammatory cytokines, chemokines, metalloproteinases and other molecules that together participate in joint degradation. The current evidence suggests the important immunoregulatory role of the gut microbiome, which can affect susceptibility to diseases and infections. An altered microbiome, a phenomenon known as gut dysbiosis, is associated with the development of inflammatory diseases. Importantly, the profile of the gut microbiome depends on dietary habits. Therefore, dietary elements and interventions can indirectly impact the progression of diseases. This review summarises the evidence on the involvement of gut dysbiosis and diet in the pathogenesis of RA.
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