氧化应激
粒体自噬
静脉
解剖
内科学
细胞生物学
化学
医学
生物
细胞凋亡
自噬
生物化学
作者
Hao Jia,Le Kang,Ben Huang,Shuyang Lu,Zhiwen Ding,Zhenhang Chen,Chunsheng Wang,Yuan Chang,Yunzeng Zou,Yongxin Sun
标识
DOI:10.1002/adbi.202400218
摘要
Venous graft decay (VGD) occurs in coronary artery bypass grafting (CABG), and ischemia-reperfusion oxidative stress injury during the operation is involved in VGD. To explore the cellular phenotypic changes during this process, a stable oxidative stress model of human saphenous vein endothelial cells (HSVECs) is constructed. Through proteomics and cell experiments, it is found that the expression of BCL2L13 is upregulated during oxidative stress of HSVECs, and BCL2L13 regulated mitophagy through receptor-mediated interaction with LC3 and plays a role in cell protection. During oxidative stress, intracellular o
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