清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Vitamin E Regulates the Collagen Contents in the Body Wall of Sea Cucumber (Apostichopus japonicus) via Its Antioxidant Effects and the TGF-β/Smads Pathway

日本使徒 海参 抗氧化剂 化学 转化生长因子 维生素C 细胞生物学 生物化学 食品科学 生物 生态学
作者
Zitong Wang,Rujian Xu,Hongbing Yang,Ruixue Li,Jun Ding,Yaqing Chang,Rantao Zuo
出处
期刊:Antioxidants [MDPI AG]
卷期号:13 (7): 847-847
标识
DOI:10.3390/antiox13070847
摘要

A 70-day feeding experiment was performed to investigate the effects of dietary vitamin E at different addition levels (0, 100, 200, and 400 mg/kg) on the growth, collagen content, antioxidant capacity, and expressions of genes related to the transforming growth factor beta (TGF-β)/Sma- and Mad-related protein (SMAD) signaling pathway in sea cucumbers (Apostichopus japonicus). The results showed that the A. japonicus in the group with 200 mg/kg vitamin E exhibited significantly higher growth rates, hydroxyproline (Hyp) and type III collagen contents, and superoxide dismutase (SOD) activity, as well as the upregulation of genes related to Tenascin, SMAD1, and TGF-β. Additionally, the A. japonicus in the group with 100 mg/kg vitamin E exhibited significantly higher body-wall indexes, denser collagen arrangements, improved texture quality, higher activities of glutathione peroxidase (GSH-Px) and peroxidase (POD), as well as the upregulation of genes related to collagen type I alpha 2 chain (COL1A2), collagen type III alpha 1 chain (COL3A1), and Sp-Smad2/3 (SMAD2/3). In contrast, the A. japonicus in the group with 400 mg/kg vitamin E showed a decrease in the growth rates, reduced Hyp contents, increased type I collagen contents, collagen fiber aggregation and a harder texture, along with the downregulation of genes related to the TGF-β/SMAD signaling pathway. Furthermore, the A. japonicus in the group with 400 mg/kg exhibited oxidative stress, reflected by the lower activities of SOD, GSH-Px, and POD. These results indicated that A. japonicus fed diets with the addition of 100–200 mg/kg vitamin E had improved collagen retention and texture quality by increasing the activities of antioxidant enzymes and the expressions of genes in the TGF-β/SMAD signaling pathway. However, the excessive addition of vitamin E (400 mg/kg) induced oxidative stress, which could increase the collagen degradation and fibrosis and pose a threat to the growth and texture quality of A. japonicus.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
10秒前
herpes完成签到 ,获得积分10
15秒前
楚襄谷完成签到 ,获得积分10
23秒前
40秒前
今后应助平平安安采纳,获得10
46秒前
6666666666完成签到 ,获得积分10
50秒前
abcdefg完成签到,获得积分10
52秒前
无辜的行云完成签到 ,获得积分0
54秒前
寒战完成签到 ,获得积分10
1分钟前
1分钟前
木耳完成签到,获得积分10
1分钟前
1分钟前
小袁搜题发布了新的文献求助10
1分钟前
Antonio完成签到 ,获得积分10
1分钟前
afli完成签到 ,获得积分0
1分钟前
木耳发布了新的文献求助10
1分钟前
无餍应助木耳采纳,获得20
1分钟前
清脆的大开完成签到,获得积分10
1分钟前
1分钟前
lynn完成签到 ,获得积分10
1分钟前
suzy-123完成签到,获得积分10
1分钟前
IvanLIu完成签到 ,获得积分10
1分钟前
科研狗完成签到 ,获得积分10
1分钟前
2分钟前
2分钟前
Cole驳回了慕青应助
2分钟前
3分钟前
hzauhzau完成签到 ,获得积分10
3分钟前
JJJJJin应助wxysanctuary采纳,获得100
3分钟前
如意2023完成签到 ,获得积分10
3分钟前
jerry完成签到 ,获得积分10
3分钟前
3分钟前
4分钟前
平平安安发布了新的文献求助10
4分钟前
4分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
4分钟前
5分钟前
属实有点拉胯完成签到 ,获得积分10
5分钟前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2500
Востребованный временем 2500
Aspects of Babylonian celestial divination : the lunar eclipse tablets of enuma anu enlil 1500
Agaricales of New Zealand 1: Pluteaceae - Entolomataceae 1040
Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation 1000
Classics in Total Synthesis IV: New Targets, Strategies, Methods 1000
体心立方金属铌、钽及其硼化物中滑移与孪生机制的研究 800
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3450460
求助须知:如何正确求助?哪些是违规求助? 3045952
关于积分的说明 9003759
捐赠科研通 2734611
什么是DOI,文献DOI怎么找? 1500096
科研通“疑难数据库(出版商)”最低求助积分说明 693341
邀请新用户注册赠送积分活动 691477