肿瘤微环境
灵芝
三萜类
半乳糖凝集素-1
免疫疗法
癌症研究
半乳糖凝集素
化学
灵芝
化疗
药理学
医学
免疫系统
免疫学
生物化学
肿瘤细胞
内科学
立体化学
食品科学
作者
Suyu Chen,Kuang-Dee Chen,Yihsiu Lin,Ssuchia Wang,Hui‐Chuan Yu,Chaohsuan Chang,Tingchun Cheng,Chiaoyun Hsieh,Jiayi Li,Hsiaohsuan Lai,Deng‐Hai Chen,Chengpo Huang
标识
DOI:10.1016/j.taap.2024.117069
摘要
Ganoderic acid T (GAT), a triterpenoid molecule of Ganoderma lucidum, exhibits anti-cancer activity; however, the underlying mechanisms remain unclear. Therefore, in this study, we aimed to investigate the anti-cancer molecular mechanisms of GAT and explore its therapeutic applications for cancer treatment. GAT exhibited potent anti-cancer activity in an ES-2 orthotopic ovarian cancer model in a humanized mouse model, leading to significant alterations in the tumor microenvironment (TME). Specifically, GAT reduced the proportion of α-SMA
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