ROR1型
单克隆抗体
癌症研究
生物
受体酪氨酸激酶
癌症
孤儿受体
抗体
癌症治疗
酪氨酸激酶
人源化抗体
受体
免疫学
遗传学
转录因子
血小板源性生长因子受体
生长因子
基因
作者
Wei Rong,Xun Liao,Jiao Li,Xiaoyu Mu,Yue Ming,Yong Peng
标识
DOI：10.1186/s12943-024-02075-y
摘要
Overexpression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) contributes to cancer cell proliferation, survival and migration, playing crucial roles in tumor development. ROR1 has been proposed as a potential therapeutic target for cancer treatment. This study aimed to develop novel humanized ROR1 monoclonal antibodies and investigate their anti-tumor effects.
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