基质
输卵管
浆液性液体
卵巢癌
生物
卵巢
癌症研究
浆液性卵巢癌
免疫系统
间质细胞
病理
癌症
免疫学
医学
免疫组织化学
遗传学
解剖
生物化学
作者
Ian P. MacFawn,Grant Magnon,Grace Gorecki,Sheryl Kunning,Rufiaat Rashid,Medard Ernest Kaiza,Huda I. Atiya,Ayana T. Ruffin,Sarah A. Taylor,T. Rinda Soong,Riyue Bao,Lan Coffman,Tullia C. Bruno
标识
DOI:10.1016/j.ccell.2024.09.007
摘要
Most high grade serous ovarian cancers (HGSOC) originate in the fallopian tube but spread to the ovary and peritoneal cavity, highlighting the need to understand antitumor immunity across HGSOC sites. Using spatial analyses, we discover that tertiary lymphoid structures (TLSs) within ovarian tumors are less developed compared with TLSs in fallopian tube or omental tumors. We reveal transcriptional differences across a spectrum of lymphoid structures, demonstrating that immune cell activity increases when residing in more developed TLSs and produce a prognostic, spatially derived TLS signature from HGSOC tumors. We interrogate TLS-adjacent stroma and assess how normal mesenchymal stem cells MSCs (nMSCs) may support B cell function and TLS, contrary to cancer-educated MSCs (CA-MSCs) which negate the prognostic benefit of our TLS signature, suggesting that pro-tumorigenic stroma could limit TLS formation.
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