双绞线
双股
DNA
双键
低聚物
鸟嘌呤
化学
DNA损伤
生物物理学
生物化学
生物
核苷酸
高分子化学
基因
作者
Harold C. Box,Jean B. Dawidzik,Edwin E. Budzinski
标识
DOI:10.1016/s0891-5849(01)00653-0
摘要
This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review.
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