尿路上皮
糖胺聚糖
医学
粘附
图层(电子)
生物物理学
解剖
泌尿科
膀胱
纳米技术
材料科学
复合材料
生物
作者
D Pantazopoulos,P. Karagiannakos,F. Sofras,A. Kostakopoulos,C. Deliveliotis,C Dimopoulos
出处
期刊:Urology
[Elsevier]
日期:1990-09-01
卷期号:36 (3): 255-259
被引量:13
标识
DOI:10.1016/0090-4295(90)80268-r
摘要
Abstract
The normal urothelium is covered by a glycosaminoglycan (GAG) layer which actsas a barrier to the adhesion of crystals. Destruction of the GAG layer increases the number of adhered crystals, and it is therefore assumed that it promotes crystal growth and stone formation. Intravesical instillation of pentosanpolysulfate, an exogenous glycosaminoglycan, after destruction of this layer reduces the adhesion of crystals to the urothelium. Intramuscular administration of carbenoxolone sodium following the experimental destruction of the GAG layer increases the rate of healing of the layer and reduces the number of adhered crystals.
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