Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation

心房颤动 医学 内科学 心脏病学 冲程(发动机) 单变量分析 队列 导管消融 优势比 烧蚀 多元分析 机械工程 工程类
作者
Irfan M. Khurram,Jane Dewire,Michael Mager,Farhan Maqbool,Stefan L. Zimmerman,Vadim Zipunnikov,Roy Beinart,Joseph E. Marine,David Spragg,Ronald D. Berger,Hiroshi Ashikaga,Saman Nazarian,Hugh Calkins
出处
期刊:Heart Rhythm [Elsevier BV]
卷期号:10 (12): 1843-1849 被引量:210
标识
DOI:10.1016/j.hrthm.2013.09.065
摘要

Atrial fibrillation (AF) is an important cause of stroke. Given the morbidity and mortality associated with stroke, the risk stratification of patients based on left atrial appendage (LAA) characteristics is of great interest.To explore the association between LAA morphology and LAA characteristics including the extent of trabeculations, orifice diameter, and length with prevalent stroke in a large cohort of patients with drug refractory AF who underwent AF ablation to develop mechanistic insight regarding the risk of stroke.An institutional cohort of 1063 patients referred for AF ablation from 2003 to 2012 was reviewed to identify patients that underwent preprocedural cardiac computed tomography (CT). LAA morphology was characterized as chicken wing, cactus, windsock, or cauliflower by using previously reported methodology. Left atrial size and LAA trabeculations, morphology, orifice diameter, and length were compared between patients with prevalent stroke and patients without prevalent stroke.Of 678 patients with CT images, 65 (10%) had prior stroke or transient ischemic attack. In univariate analyses, prevalent heart failure (7.7% in cases vs 2.8% in controls; P = .033), smaller LAA orifice (2.26 ± 0.52 cm vs 2.78 ± 0.71 cm ; P < .001), shorter LAA length (5.06 ± 1.17 cm vs 5.61 ± 1.17 cm; P < .001), and extensive LAA trabeculations (27.7% vs 14.4%; P = .019) were associated with stroke. LAA morphologies were unassociated with stroke risk. In multivariable analysis, smaller LAA orifice diameter and extensive LAA trabeculations remained independently associated with thromboembolic events.The extent of LAA trabeculations and smaller LAA orifice diameter are associated with prevalent stroke and may mediate the previously described association of cauliflower LAA morphology with stroke.
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