十二指肠大乳头
医学
原发性硬化性胆管炎
自身免疫性胰腺炎
胃肠病学
十二指肠
内科学
胰腺炎
内镜逆行胰胆管造影术
病理
疾病
作者
Kensuke Kubota,Shingo Kato,Tomoyuki Akiyama,Masato Yoneda,Koji Fujita,Masami Ogawa,Masahiko Inamori,Noritoshi Kobayashi,Satoru Saito,Yukio Kakuta,Hisashi Ohshiro,Atsushi Nakajima
标识
DOI:10.1016/j.gie.2008.08.013
摘要
Differentiating primary sclerosing cholangitis (PSC) and sclerosing cholangitis caused by autoimmune pancreatitis (SC-AIP) is often challenging. Recently, endoscopic findings of the duodenal papilla in cases with AIP or PSC were reported by Unno and Parlak, although the endoscopic differentiation of these 2 conditions has not yet been fully clarified.Our purpose was to clarify the endoscopic findings of the duodenal papilla in patients with SC-AIP and those with PSC and to determine criteria for the differentiation of these conditions.Case series.Retrospective.Twenty-seven patients with SC-AIP and 12 patients with PSC who had undergone ERCP were identified from our database. We reviewed these records to determine whether the duodenal papillary findings (swollen papilla/normal papilla/small papilla) might be potentially useful for differentiating SC-AIP and PSC. Immunohistopathological findings for the duodenal papilla were also examined by using immunoglobulin G4 (IgG4) among the infiltrating plasma cells.ERCP, biopsy specimen taken from duodenal papilla.The presence of a swollen duodenal papilla with IgG4-positive plasma cells was useful for discriminating SC-AIP from with PSC.A swollen duodenal papilla was observed in 63% (17/27) of the patients with SC-AIP, whereas there was no swelling of the duodenal papilla of the patients with PSC. A small papilla was recognized in 50% (6/12) of the patients with PSC. IgG4-positive plasma cells in the duodenal papilla were significantly detected in the patients with SC-AIP but not in the patients with PSC.Single-center study.Characteristic duodenal endoscopic papillary features in patients with SC-AIP, such as a swollen duodenal papilla and positive immunostaining for IgG4, might be helpful for discriminating this condition from PSC.
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