Differential skeletal response in adult and aged rats to independent and combinatorial stimulation with pulsed electromagnetic fields and mechanical vibration

合成代谢 去卵巢大鼠 全身振动 骨细胞 骨质疏松症 Wnt信号通路 合成代谢剂 医学 刺激 内分泌学 内科学 成骨细胞 化学 雌激素 信号转导 生物化学 物理 量子力学 体外 振动
作者
Jing Cai,Xi Shao,Zedong Yan,Xiyu Liu,Yongqing Yang,Erping Luo,Da Jing
出处
期刊:The FASEB Journal [Wiley]
卷期号:34 (2): 3037-3050 被引量:19
标识
DOI:10.1096/fj.201902779r
摘要

Pulsed electromagnetic fields (PEMFs) and whole-body vibration (WBV) are proved to partially preserve bone mass/strength in hindlimb-unloaded and ovariectomized animals. However, the potential age-dependent skeletal response to either PEMF or WBV has not been fully investigated. Moreover, whether the coupled "mechano-electro-magnetic" signals can induce greater osteogenic potential than single stimulation remains unknown. Herein, 5-month-old or 20-month-old rats were assigned to the Control, PEMF, WBV, and PEMF + WBV groups. After 8-week treatment, single PEMF/WBV enhanced bone mass, strength, and anabolism in 5-month-old rats, but not in 20-month-old rats. PEMF + WBV induced greater increase of bone quantity, quality, and anabolism than single PEMF/WBV in young adult rats. PEMF + WBV also inhibited bone loss in elderly rats by primarily improving osteoblast and osteocyte activity, but had no effects on bone resorption. PEMF + WBV upregulated the expression of various canonical Wnt ligands and downstream molecules (p-GSK-3β and β-catenin), but had no impacts on noncanonical Wnt5a expression in aged skeleton, revealing the potential involvement of canonical Wnt signaling in bone anabolism of PEMF + WBV. This study not only reveals much weaker responsiveness of aged skeleton to single PEMF/WBV relative to young adult skeleton, but also presents a novel noninvasive approach based on combinatorial treatment with PEMF + WBV for improving bone health and preserving bone quantity/quality (especially for age-related osteoporosis) with stronger anabolic effects.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
可可发布了新的文献求助10
刚刚
2秒前
2秒前
飞鱼发布了新的文献求助20
3秒前
4秒前
量子星尘发布了新的文献求助10
5秒前
6秒前
wtt发布了新的文献求助10
7秒前
7秒前
大胆的若灵完成签到,获得积分10
7秒前
傅寻菱完成签到,获得积分10
8秒前
9秒前
Leslie完成签到,获得积分10
9秒前
11秒前
sandra发布了新的文献求助10
11秒前
11秒前
11秒前
科目三应助咪咪采纳,获得10
13秒前
14秒前
华仔应助欣慰的乌冬面采纳,获得10
14秒前
曹小仙男发布了新的文献求助10
16秒前
18秒前
张大泽同学发布了新的文献求助100
18秒前
19秒前
20秒前
大个应助小麦采纳,获得10
22秒前
ywl发布了新的文献求助10
22秒前
22秒前
23秒前
24秒前
飞翔的小鸟完成签到 ,获得积分10
24秒前
24秒前
25秒前
思源应助陈博文采纳,获得10
25秒前
伽拉发布了新的文献求助10
26秒前
学术蛔虫完成签到 ,获得积分10
26秒前
27秒前
林子完成签到,获得积分10
27秒前
澡雪发布了新的文献求助10
27秒前
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975661
求助须知:如何正确求助?哪些是违规求助? 3520000
关于积分的说明 11200535
捐赠科研通 3256410
什么是DOI,文献DOI怎么找? 1798247
邀请新用户注册赠送积分活动 877490
科研通“疑难数据库(出版商)”最低求助积分说明 806390