Systemic inflammation in both open-angle and angle-closure glaucoma: role of platelet-to-lymphocyte ratio

AIM: To analyse the effect of systemic infl ammatory status in patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) by calculating platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR).METHODS: This retrospective case-control study included 200 patients with POAG, 22 patients with PACG and 100 healthy subjects.The participants' white-blood-cell, lymphocyte, neutrophil, and platelet counts were recorded from previous blood assays.NLR and PLR were calculated manually.Results were compared among the groups.RESULTS: Both the POAG and PACG groups had higher platelet counts and PLR values than the control group (p=0.001 and p=0.001; respectively).The difference in NLR between POAG, PACG and control groups was not statistically signifi cant (p=0.076).The POAG group had higher NLR values than the control (p=0.035).CONCLUSION: Both the POAG and the PACG groups exhibited higher platelet and PLR levels than the control.These results indicate a potential role of systemic infl ammation in the pathogenesis of POAG and PACG (Tab.4, Fig. 1, Ref. 35).Text in PDF www.elis.sk