疾病
医学
心理干预
生命历程法
肥胖
风险因素
心理学
儿童肥胖
观察研究
发展心理学
精神科
超重
内分泌学
内科学
作者
Jessie R. Baldwin,Andrea Danese
标识
DOI:10.1177/0308575919856175
摘要
Childhood maltreatment is a risk factor for poor physical health outcomes in later life, such as cardiovascular disease and type 2 diabetes. In order to target preventive interventions to reduce this risk, it is important to understand the biological mechanisms linking childhood maltreatment to cardiometabolic disorders. Research reviewed here suggests that maltreated children show alterations in biological systems relating to metabolism and the immune system which could, in turn, increase the risk of long-term cardiometabolic disease risk. Specifically, maltreated children show an elevated risk of obesity in adulthood and greater inflammation levels in adolescence and adulthood. These findings from observational studies of humans are consistent with evidence from experimental animal models showing the causal effects of early life stress on obesity and immune function. To help prevent maltreated children from developing cardiometabolic disease later in life, clinical assessment and treatment should focus on physical as well as mental health.
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